Genome-wide association study of delay discounting in Heterogenous Stock rats.

ABSTRACT: Delay discounting refers to the behavioral tendency to devalue rewards as a function of their delay in receipt. Heightened delay discounting has been associated with substance use disorders, as well as multiple co-occurring psychopathologies. Genetic studies in humans and animal models have established that delay discounting is a heritable trait, but only a few specific genes have been associated with delay discounting. Here, we aimed to identify novel genetic loci associated with delay discounting through a genome-wide association study (GWAS) using Heterogenous Stock rats, a genetically diverse outbred population derived from eight inbred founder strains. We assessed delay discounting in 650 male and female rats using an adjusting amount procedure in which rats chose between smaller imme

SUBMITTER: Lara MK 

PROVIDER: S-EPMC10760013 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature