Transposable elements may enhance antiviral resistance in HIV-1 elite controllers.

ABSTRACT: Less than 0.5% of people living with HIV-1 are elite controllers (ECs) - individuals who have a replication-competent viral reservoir in their CD4⁺ T cells but maintain undetectable plasma viremia without the help of antiretroviral therapy. While the EC CD4⁺ T cell transcriptome has been investigated for gene expression signatures associated with disease progression (or, in this case, a lack thereof), the expression and regulatory activity of transposable elements (TEs) in ECs has not been explored. Yet previous studies have established that TEs can directly impact the immune response to pathogens, including HIV-1. Thus, we hypothesize that the regulatory activities of TEs could contribute to the natural resistance of ECs against HIV-1. We perform a TE-centric analysi

SUBMITTER: Singh M 

PROVIDER: S-EPMC10760019 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature