Dopamine enhances GABA_A receptor-mediated current amplitude in a subset of intrinsically photosensitive retinal ganglion cells.

ABSTRACT: Neuromodulation in the retina is crucial for effective processing of retinal signal at different levels of illuminance. Intrinsically photosensitive retinal ganglion cells (ipRGCs), the neurons that drive non-image forming visual functions, express a variety of neuromodulatory receptors that tune intrinsic excitability as well as synaptic inputs. Past research has examined actions of neuromodulators on light responsiveness of ipRGCs, but less is known about how neuromodulation affects synaptic currents in ipRGCs. To better understand how neuromodulators affect synaptic processing in ipRGC, we examine actions of opioid and dopamine agonists have on inhibitory synaptic currents in ipRGCs. Although μ-opioid receptor (MOR) activation had no effect on γ-aminobutyric acid (GABA) currents, dopami

SUBMITTER: Bergum N 

PROVIDER: S-EPMC10760026 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature