Cryptic proteins translated from deletion-containing viral genomes dramatically expand the influenza virus proteome.

ABSTRACT: Productive infections by RNA viruses require faithful replication of the entire genome. Yet many RNA viruses also produce deletion-containing viral genomes (DelVGs), aberrant replication products with large internal deletions. DelVGs interfere with the replication of wild-type virus and their presence in patients is associated with better clinical outcomes as they. The DelVG RNA itself is hypothesized to confer this interfering activity. DelVGs antagonize replication by out-competing the full-length genome and triggering innate immune responses. Here, we identify an additionally inhibitory mechanism mediated by a new class of viral proteins encoded by DelVGs. We identified hundreds of cryptic viral proteins translated from DelVGs. These DelVG-encoded proteins (DPRs) include canonical viral

SUBMITTER: Ranum JN 

PROVIDER: S-EPMC10760031 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature