Broad H3K4me3 Domain Is Associated with Spatial Coherence during Mammalian Embryonic Development.

ABSTRACT: It is well known that the chromatin states play a major role in cell-fate decision and cell-identity maintenance; however, the spatial variation of chromatin states in situ remains poorly characterized. Here, by leveraging recently available spatial-CUT&Tag data, we systematically characterized the global spatial organization of the H3K4me3 profiles in a mouse embryo. Our analysis identified a subset of genes with spatially coherent H3K4me3 patterns, which together delineate the tissue boundaries. The spatially coherent genes are strongly enriched with tissue-specific transcriptional regulators. Remarkably, their corresponding genomic loci are marked by broad H3K4me3 domains, which is distinct from the typical H3K4me3 signature. Spatial transition across tissue boundaries is associa

SUBMITTER: Cao X 

PROVIDER: S-EPMC10760050 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature