MiRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity.

ABSTRACT: Activity-dependent protein synthesis is crucial for many long-lasting forms of synaptic plasticity. However, our understanding of the translational mechanisms controlling inhibitory synapses is limited. One distinct form of inhibitory long-term potentiation (iLTP) enhances postsynaptic clusters of GABA_ARs and the primary inhibitory scaffold, gephyrin, to promote sustained synaptic strengthening. While we previously found that persistent iLTP requires mRNA translation, the precise mechanisms controlling gephyrin translation during this process remain unknown. Here, we identify miR153 as a novel regulator of Gphn mRNA translation which controls gephyrin protein levels and synaptic clustering, ultimately impacting GABAergic synaptic structure and function. We find that iLTP

SUBMITTER: Welle TM 

PROVIDER: S-EPMC10760056 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature