The role of the C. albicans transcriptional repressor NRG1 during filamentation and disseminated candidiasis is strain-dependent.

ABSTRACT: Candida albicans is one of the most common causes of superficial and invasive fungal disease in humans. Its ability to cause disease has been closely linked to its ability to undergo a morphological transition from budding yeast to filamentous forms (hyphae and pseudohyphae). The ability of C. albicans strains isolated from patients to undergo filamentation varies significantly. In addition, the filamentation phenotypes of mutants involving transcription factors that positively regulate hyphal morphogenesis can also vary from strain to strain. Here, we characterized the virulence, in vitro and in vivo filamentation, and in vitro and in vivo hypha-associated gene expression profiles of four poorly filamenting C. albicans isolates and their corresponding deletion mutants

SUBMITTER: Wakade RS 

PROVIDER: S-EPMC10760072 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature