Predicting neutralization susceptibility to combination HIV-1 monoclonal broadly neutralizing antibody regimens.

ABSTRACT: Combination monoclonal broadly neutralizing antibodies (bnAbs) are currently being developed for preventing HIV-1 infection. Recent work has focused on predicting in vitro neutralization potency of both individual bnAbs and combination regimens against HIV-1 pseudoviruses using Env sequence features. To predict in vitro combination regimen neutralization potency against a given HIV-1 pseudovirus, previous approaches have applied mathematical models to combine individual-bnAb neutralization and have predicted this combined neutralization value; we call this the combine-then-predict (CP) approach. However, prediction performance for some individual bnAbs has exceeded that for the combination, leading to another possibility: combining the individual-bnAb predicted values and using these to pr

SUBMITTER: Williamson BD 

PROVIDER: S-EPMC10760080 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature