A Boundary Element Method of Bidomain Modeling for Predicting Cellular Responses to Electromagnetic Fields.

ABSTRACT:

Objective

Commonly used cable equation-based approaches for determining the effects of electromagnetic fields on excitable cells make several simplifying assumptions that could limit their predictive power. Bidomain or "whole" finite element methods have been developed to fully couple cells and electric fields for more realistic neuron modeling. Here, we introduce a novel bidomain integral equation designed for determining the full electromagnetic coupling between stimulation devices and the intracellular, membrane, and extracellular regions of neurons.

Methods

Our proposed boundary element formulation offers a solution to an integral equation that connects the device, tissue inhomogeneity, and cell membrane-induced E-fields. We solve this integral equation using first-order

SUBMITTER: Czerwonky DM 

PROVIDER: S-EPMC10760105 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature