Assessment of Neurovascular Uncoupling: APOE Status is a Key Driver of Early Metabolic and Vascular Dysfunction.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common cause of dementia worldwide, with apolipoprotein ε4 (APOE^ε4) being the strongest genetic risk factor. Current clinical diagnostic imaging focuses on amyloid and tau; however, new methods are needed for earlier detection.

Methods

PET imaging of ¹⁸F-FDG and ⁶⁴Cu-PTSM was used to assess metabolism-perfusion profiles in both sexes of aging C57BL/6J, and APOE^ε3/ε3, APOE^ε4/ε4, and APOE^ε3/ε4.

Results

Across all strains, 8 months is a key transition stage. Females exhibited the greatest number of regional changes for both tracers, which correlate with GO-term enrichments for glucose metabolism, perfusi

SUBMITTER: Onos K 

PROVIDER: S-EPMC10760108 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature