Highly accelerated dynamic acquisition of 3D grid-tagged hyperpolarized-gas lung images using compressed sensing.

ABSTRACT:

Purpose

To develop and test compressed sensing-based multiframe 3D MRI of grid-tagged hyperpolarized gas in the lung.

Theory and methods

Applying grid-tagging RF pulses to inhaled hyperpolarized gas results in images in which signal intensity is predictably and sparsely distributed. In the present work, this phenomenon was used to produce a sampling pattern in which k-space is undersampled by a factor of approximately seven, yet regions of high k-space energy remain densely sampled. Three healthy subjects received multiframe 3D ³ He tagging MRI using this undersampling method. Images were collected during a single exhalation at eight timepoints spanning the breathing cycle from end-of-inhalation to end-of-exhalation. Grid-tagged images were used to generate 3D dis

SUBMITTER: Garrison WJ 

PROVIDER: S-EPMC10760126 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature