Magnetogenetic stimulation inside MRI induces spontaneous and evoked changes in neural circuits activity in rats.

ABSTRACT: The ability to modulate specific neural circuits and simultaneously visualize and measure brain activity with MRI would greatly impact understanding brain function in health and disease. The combination of neurostimulation methods and MRI in animal models have already shown promise in elucidating fundamental mechanisms associated with brain activity. We developed an innovative magnetogenetics neurostimulation technology that can trigger neural activity through magnetic fields. Similar to other genetic-based neuromodulation methods, magnetogenetics offers cell-, area- and temporal-specific control of neural activity. However, the magnetogenetics protein (Electromagnetic Preceptive Gene (EPG)) are activated by non-invasive magnetic fields, providing a unique way to target neural circuits by

SUBMITTER: Chuang KH 

PROVIDER: S-EPMC10760131 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature