Transgelin 2 guards T cell lipid metabolic programming and anti-tumor function.

ABSTRACT: Mounting effective immunity against pathogens and tumors relies on the successful metabolic programming of T cells by extracellular fatty acids^1-3. During this process, fatty-acid-binding protein 5 (FABP5) imports lipids that fuel mitochondrial respiration and sustain the bioenergetic requirements of protective CD8⁺ T cells^4,5. Importantly, however, the mechanisms governing this crucial immunometabolic axis remain unexplored. Here we report that the cytoskeletal organizer Transgelin 2 (TAGLN2) is necessary for optimal CD8⁺ T cell fatty acid uptake, mitochondrial respiration, and anti-cancer function. We found that TAGLN2 interacts with FABP5, enabling the surface localization of this lipid importer on activated CD8⁺ T cells. Analysis o

SUBMITTER: Hwang SM 

PROVIDER: S-EPMC10760247 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature