Elevated plasma matrix metalloproteinases associate with <i>Mycobacterium tuberculosis</i> blood stream infection and mortality in HIV-associated tuberculosis.

ABSTRACT: Mortality from HIV-associated tuberculosis (HIV-TB) is high, particularly among hospitalised patients. In 433 people living with HIV admitted to hospital with symptoms of TB, we investigated plasma matrix metalloproteinases (MMP) and matrix-derived biomarkers in relation to TB diagnosis, mortality and Mycobacterium tuberculosis (Mtb) blood stream infection (BSI). Compared to other diagnoses, MMP-8 was elevated in confirmed TB and in Mtb-BSI, positively correlating with extracellular matrix breakdown products. Baseline MMP-3, -7, -8, -10 and procollagen III N-terminal propeptide (PIIINP) associated with Mtb-BSI and 12-week mortality. These findings implicate MMP dysregulation in pathophysiology of advanced HIV-TB and support MMP inhibition as a host-directed ther

SUBMITTER: Walker NF 

PROVIDER: S-EPMC10760259 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature