Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia.

ABSTRACT:

Background

The ganglionic eminences are fetal-specific structures that give rise to gamma-aminobutyric acid (GABA)- and acetylcholine- releasing neurons of the forebrain. Given evidence for GABAergic and cholinergic disturbances in schizophrenia, as well as an early neurodevelopmental component to the disorder, we tested the potential involvement of developing cells of the ganglionic eminences in mediating genetic risk for the condition.

Study design

We combined data from a recent large-scale genome-wide association study of schizophrenia with single cell RNA sequencing data from the human ganglionic eminences to test enrichment of schizophrenia risk variation in genes with high expression specificity for particular developing cell populations within these structures. We add

SUBMITTER: Cameron D 

PROVIDER: S-EPMC10760267 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature