Prediction of post-PCV13 pneumococcal evolution using invasive disease data enhanced by inverse-invasiveness weighting.

ABSTRACT:

Background

After introduction of pneumococcal conjugate vaccines (PCVs), serotype replacement occurred in the population of Streptococcus pneumoniae. Predicting which pneumococcal clones and serotypes will become more common in carriage after vaccination can enhance vaccine design and public health interventions, while also improving our understanding of pneumococcal evolution. We sought to use invasive disease data to assess how well negative frequency-dependent selection (NFDS) models could explain pneumococcal carriage population evolution in the post-PCV13 epoch by weighting invasive data to approximate strain proportions in the carriage population.

Methods

Invasive pneumococcal isolates were collected and sequenced during 1998-2018 by the Active Bacterial Core su

SUBMITTER: Qiu X 

PROVIDER: S-EPMC10760274 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature