Dataset Information

Amount and intensity of physical activity and risk of incident cancer in the UK Biobank.

ABSTRACT:

Importance

The influence of total daily and light intensity activity on cancer risk remains unclear, as most existing knowledge is drawn from studies relying on self-reported leisure-time activities of moderate-vigorous intensity.

Objective

To investigate associations between total daily activity, including step counts, and activity intensity on incident cancer risk.

Design setting and participants

Prospective analysis of cancer-free UK Biobank participants who wore accelerometers for 7-days (between 2013-2015), followed for cancer incidence through national registries (mean follow-up 5.8 years (SD=1.3)).

Exposures

Time-series machine learning models derived daily total activity (average acceleration), behaviour time, step counts, and peak 30-minute cadence from wrist-based accelerometer data.

Main outcomes and measures

A composite cancer outcome of 13 cancers previously associated with low physical activity (bladder, breast, colon, endometrial, oesophageal adenocarcinoma, gastric cardia, head and neck, kidney, liver, lung, myeloid leukaemia, myeloma, and rectum) based on previous studies of self-reported activity. Cox proportional hazards regression models estimated hazard ratios (HR) and 95% confidence intervals (CI), adjusted for age, sex, ethnicity, smoking, alcohol, education, Townsend Deprivation Index, and reproductive factors. Associations of reducing sedentary time in favour of increased light and moderate-vigorous activity were examined using compositional data analyses.

Results

Among 86 556 participants (mean age 62.0 years (SD=7.9) at accelerometer assessment), 2 669 cancers occurred. Higher total physical activity was associated with a lower overall cancer risk (HR_1SD=0.85, [95%CI 0.81-0.89]). On average, reallocating one hour/day from sedentary behaviour to moderate-vigorous physical activity was associated with a lower risk (HR=0.92, [0.89-0.95]), as was reallocating one hour/day to light-intensity physical activity (HR=0.94, [0.92-0.96]). Compared to individuals taking 5 000 daily steps, those who took 9 000 steps had an 18% lower risk of physical-activity-related cancer (HR=0.82, [0.74-0.90]). We found no significant association with peak 30-minute cadence after adjusting for total steps.

Conclusion and relevance

Higher total daily physical activity and less sedentary time, in favour of both light and moderate-vigorous intensity activity, were associated with a lower risk of certain cancers. For less active adults, increasing step counts by 4 000 daily steps may be a practical public health intervention for lowering the risk of some cancers.

SUBMITTER: Shreves AH

PROVIDER: S-EPMC10760289 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Amount and intensity of physical activity and risk of incident cancer in the UK Biobank.

Shreves Alaina H AH Small Scott R SR Walmsley Rosemary R Chan Shing S Saint-Maurice Pedro F PF Moore Steven C SC Papier Keren K Gaitskell Kezia K Travis Ruth C RC Matthews Charles E CE Doherty Aiden A

medRxiv : the preprint server for health sciences 20231204

<h4>Importance</h4>The influence of total daily and light intensity activity on cancer risk remains unclear, as most existing knowledge is drawn from studies relying on self-reported leisure-time activities of moderate-vigorous intensity.<h4>Objective</h4>To investigate associations between total daily activity, including step counts, and activity intensity on incident cancer risk.<h4>Design setting and participants</h4>Prospective analysis of cancer-free UK Biobank participants who wore acceler ...[more]

PMID: 38168300

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Dataset Information

Amount and intensity of physical activity and risk of incident cancer in the UK Biobank.

Importance

Objective

Design setting and participants

Exposures

Main outcomes and measures

Results

Conclusion and relevance

Publications

Amount and intensity of physical activity and risk of incident cancer in the UK Biobank.

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