Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.

ABSTRACT: Prediction from polygenic scores may be confounded sources of passive gene-environment correlation (rGE; e.g. population stratification, assortative mating, and environmentally mediated effects of parental genotype on child phenotype). Using genomic data from 10,000 twin pairs, we asked whether polygenic scores from the recent externalising genome-wide association study predicted conduct problems, ADHD symptomology and callous-unemotional traits, and whether these predictions are biased by rGE. We ran regression models including within-family and between-family polygenic scores, to separate the direct genetic influence on a trait from environmental influences that correlate with genes (indirect genetic effects). Findings suggested that this externalising polygenic score is a good index of

SUBMITTER: Bright JK 

PROVIDER: S-EPMC10760293 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature