Strain-level characterization of health-associated bacterial consortia that colonize the human gut during infancy.

ABSTRACT:

Background

The human gut microbiome develops rapidly during infancy, a key window of development coinciding with maturation of the adaptive immune system. However, little is known of the microbiome growth dynamics over the first few months of life and whether there are any generalizable patterns across human populations. We performed metagenomic sequencing on stool samples (n=94) from a cohort of infants (n=15) at monthly intervals in the first six months of life, augmenting our dataset with seven published studies for a total of 4,441 metagenomes from 1,162 infants.

Results

Strain-level de novo analysis was used to identify 592 of the most abundant organisms in the infant gut microbiome. Previously unrecognized consortia were identified which exhibited highly correla

SUBMITTER: Minot SS 

PROVIDER: S-EPMC10760300 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature