Association between sex hormones and anti-S/RBD antibody responses to COVID-19 vaccines in healthcare workers.

ABSTRACT: Healthcare workers (HCWs) are the target population for vaccination against coronavirus disease (COVID-19) as they are at a high risk of exposure and transmission of pathogens to patients. Neutralizing antibodies developed after COVID-19 vaccination decline within few months of vaccination. Several factors, including age and sex, can affect the intensity, efficacy, and duration of immune response to vaccines. However, sex-specific analyses of humoral responses to COVID-19 vaccines are lacking. This study aimed to evaluate sex-based differences in anti-S/RBD (Receptor Binding Domain) responses at three different time points after the second dose of mRNA COVID-19 vaccine in HCWs in relation to age, and to investigate the role of sex hormones as potential markers of response. Anti-S/RBD level

SUBMITTER: Anticoli S 

PROVIDER: S-EPMC10760357 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature