Human transcriptional signature of protection after Plasmodium falciparum immunization and infectious challenge via mosquito bites.

ABSTRACT: The identification of immune correlates of protection against infectious pathogens will accelerate the design and optimization of recombinant and subunit vaccines. Systematic analyses such as immunoprofiling including serological, cellular, and molecular assessments supported by computational tools are key to not only identify correlates of protection but also biomarkers of disease susceptibility. The current study expands our previous cellular and serological profiling of vaccine-induced responses to a whole parasite malaria vaccine. The irradiated sporozoite model was chosen as it is considered the most effective vaccine against malaria. In contrast to whole blood transcriptomics analysis, we stimulated peripheral blood mononuclear cells (PBMC) with sporozoites and enriched for antigen-s

SUBMITTER: Mura M 

PROVIDER: S-EPMC10760396 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature