Recent advances in human norovirus research and implications for candidate vaccines.

ABSTRACT:

Introduction

Noroviruses are a leading cause of acute gastroenteritis worldwide. An estimated 21 million illnesses in the United States and upwards of 684 million illnesses worldwide are attributed to norovirus infection. There are no licensed vaccines to prevent norovirus, but several candidates are in development.

Areas covered

We review recent advances in molecular epidemiology of noroviruses, immunology, and in-vitro cultivation of noroviruses using human intestinal enteroids. We also provide an update on the status of norovirus vaccine candidates.

Expert opinion

Molecular epidemiological studies confirm the tremendous genetic diversity of noroviruses, the continuous emergence of new recombinant strains, and the predominance of GII.4 viruses worldwide. Duration of

SUBMITTER: Cates JE 

PROVIDER: S-EPMC10760411 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature