Proteome-wide structural analysis quantifies structural conservation across distant species.

ABSTRACT: Traditional evolutionary biology research mainly relies on sequence information to infer evolutionary relationships between genes or proteins. In contrast, protein structural information has long been overlooked, although structures are more conserved and closely linked to the functions than the sequences. To address this gap, we conducted a proteome-wide structural analysis using experimental and computed protein structures for organisms from the three distinct domains, including Homo sapiens (eukarya), Escherichia coli (bacteria), and Methanocaldococcus jannaschii (archaea). We reveal the distribution of structural similarity and sequence identity at the genomic level and characterize the twilight zone, where signals obtained from sequence alignment are blurred and e

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10760455 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature