Permeant cations modulate pore dynamics and gating of TRPV1 ion channels.

ABSTRACT: The transient receptor vanilloid 1 (TRPV1) is a non-selective ion channel, which is activated by several chemical ligands and heat. We have previously shown that activation of TRPV1 by different ligands results in single-channel openings with different conductance, suggesting that the selectivity filter is highly dynamic. TRPV1 is weakly voltage dependent; here, we sought to explore whether the permeation of different monovalent ions could influence the voltage dependence of this ion channel. By using single-channel recordings, we show that TRPV1 channels undergo rapid transitions to closed states that are directly connected to the open state, which may result from structural fluctuations of their selectivity filter. Moreover, we demonstrate that the rates of these transitions are influenc

SUBMITTER: Garcia-Avila M 

PROVIDER: S-EPMC10760480 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature