Clostridioides difficile carriage in animals and the associated changes in the host fecal microbiota.

ABSTRACT: The relationship between the gut microbiota and Clostridioides difficile, and its role in the severity of C. difficile infection in humans is an area of active research. Intestinal carriage of toxigenic and non-toxigenic C. difficile strains, with and without clinical signs, is reported in animals, however few studies have looked at the risk factors associated with C. difficile carriage and the role of the host gut microbiota. Here, we isolated and characterized C. difficile strains from different animal species (predominantly canines (dogs), felines (cats), and equines (horses)) that were brought in for tertiary care at North Carolina State University Veterinary Hospital. C. difficile strains were characterized by toxin gene profiling, fluorescent PCR ribotyping, and antimicrobial suscept

SUBMITTER: Thanissery R 

PROVIDER: S-EPMC10760528 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature