Duhuo Jisheng Decoction regulates intracellular zinc homeostasis by enhancing autophagy via PTEN/Akt/mTOR pathway to improve knee cartilage degeneration.

ABSTRACT:

Background

Articular cartilage and cartilage matrix degradation are key pathological changes occurring in the early stage of knee osteoarthritis (KOA). However, currently, there are limited strategies for early prevention and treatment of KOA. Duhuo Jisheng Decoction (DHJSD) is a formula quoted in Bei Ji Qian jin Yao Fang, which was compiled by Sun Simiao in the Tang Dynasty of China. As a complementary therapy, it is widely used to treat early-stage KOA in China; however, its mechanism has not been completely elucidated.

Objective

This study investigated the potential role of DHJSD in preventing cartilage degradation and the underlying mechanism.

Methods

A rat model of KOA model was established via the Hulth method. Subsequently, 25 rats were randomized into sham (sa

SUBMITTER: Wang YH 

PROVIDER: S-EPMC10760926 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature