Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation.

ABSTRACT: Physiologic activation of estrogen receptor α (ERα) is mediated by estradiol (E2) binding in the ligand-binding pocket of the receptor, repositioning helix 12 (H12) to facilitate binding of coactivator proteins in the unoccupied coactivator binding groove. In breast cancer, activation of ERα is often observed through point mutations that lead to the same H12 repositioning in the absence of E2. Through expanded genetic sequencing of breast cancer patients, we identified a collection of mutations located far from H12 but nonetheless capable of promoting E2-independent transcription and breast cancer cell growth. Using machine learning and computational structure analyses, this set of mutants was inferred to act distinctly from the H12-repositioning mutants and instead was associated with con

SUBMITTER: Irani S 

PROVIDER: S-EPMC10760953 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature