Gut microbiome responds to alteration in female sex hormone status and exacerbates metabolic dysfunction.

ABSTRACT: Women are at significantly greater risk of metabolic dysfunction after menopause, which subsequently leads to numerous chronic illnesses. The gut microbiome is associated with obesity and metabolic dysfunction, but its interaction with female sex hormone status and the resulting impact on host metabolism remains unclear. Herein, we characterized inflammatory and metabolic phenotypes as well as the gut microbiome associated with ovariectomy and high-fat diet feeding, compared to gonadal intact and low-fat diet controls. We then performed fecal microbiota transplantation (FMT) using gnotobiotic mice to identify the impact of ovariectomy-associated gut microbiome on inflammatory and metabolic outcomes. We demonstrated that ovariectomy led to greater gastrointestinal permeability and inflammat

SUBMITTER: Cross TL 

PROVIDER: S-EPMC10761013 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature