Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis.

ABSTRACT: Interferon regulatory factor 4 (IRF4) is a master transcription factor that regulates T helper cell (Th) differentiation. It interacts with the Basic leucine zipper transcription factor, ATF-like (BATF), depletion of which in CD4⁺ T cells abrogates acute graft-versus-host disease (aGVHD)-induced colitis. Here, we investigated the immune-regulatory role of Irf4 in a mouse model of MHC-mismatched bone marrow transplantation. We found that recipients of allogenic Irf4^-/- CD4⁺ T cells developed less GVHD-related symptoms. Transcriptome analysis of re-isolated donor Irf4^-/- CD4⁺ T helper (Th) cells, revealed gene expression profiles consistent with loss of effector T helper cell signatures and enrichment o

SUBMITTER: Frueh JT 

PROVIDER: S-EPMC10761041 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature