Tumor-derived CircRNA_102191 promotes gastric cancer and facilitates M2 macrophage polarization.

ABSTRACT:

Background

Gastric cancer is a common malignant tumor of the digestive tract and the fourth leading cause of death from cancer-related diseases. In recent years, many studies have found that circular RNAs play an important role in cancer. Tumor-associated macrophages (TAMs) are also critical for tumor progression.

Objective

This study examined the role of circRNA_102191 in gastric cancer progression.

Methods

The relative mRNA levels were determined by qRT-PCR. Western blotting and ELISA were used to detect the protein levels. In vitro proliferation was assessed using CCK8 and clonogenic assays. The migration and invasion of cell lines were assessed by transwell-based assays. The interactions between molecules were detected using a luciferase reporter assay. M0 macroph

SUBMITTER: Yao M 

PROVIDER: S-EPMC10761078 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature