Isolation of three different sizes of exosomes in an Asian population with different retinal diseases before and after treatment: preliminary results.

ABSTRACT: Exosomes are membranous structures measuring between 40-120 nm that are secreted by various cells of the human body into the body fluid system. Exosomes contain proteins, mRNA, miRNA, and signaling molecules, and physiologically they assist in the intercellular transport of proteins and RNA molecules. In this study, we used an immunoaffinity filter paper platform combined with scanning electron microscopy and microfluidic systems to detect the size of exosomes within the aqueous humor. Eight aqueous humor samples showed three distinct sizes of exosomes that were significantly different on scanning electron microscopy(P < 0.01). We further used nanoparticle tracking analysis to assess the size distribution of exosomes within the aqueous humor. We found significantly different distrib

SUBMITTER: Wu SY 

PROVIDER: S-EPMC10761085 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature