Epigenetic regulation of autophagy-related genes: Implications for neurodevelopmental disorders.

ABSTRACT: Macroautophagy/autophagy is an evolutionarily highly conserved catabolic process that is important for the clearance of cytosolic contents to maintain cellular homeostasis and survival. Recent findings point toward a critical role for autophagy in brain function, not only by preserving neuronal health, but especially by controlling different aspects of neuronal development and functioning. In line with this, mutations in autophagy-related genes are linked to various key characteristics and symptoms of neurodevelopmental disorders (NDDs), including autism, micro-/macrocephaly, and epilepsy. However, the group of NDDs caused by mutations in autophagy-related genes is relatively small. A significant proportion of NDDs are associated with mutations in genes encoding epigenetic regulatory prote

SUBMITTER: Lewerissa EI 

PROVIDER: S-EPMC10761153 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature