NIR-switchable local hydrogen generation by tandem bimetallic MOFs nanocomposites for enhanced chemodynamic therapy.

ABSTRACT: The inadequate quantity of hydrogen peroxide (H₂O₂) in cancer cells promptly results in the constrained success of chemodynamic therapy (CDT). Significant efforts made throughout the years; nevertheless, researchers are still facing the great challenge of designing a CDT agent and securing H₂O₂ supply within the tumor cell. In this study, taking advantage of H₂O₂ level maintenance mechanism in cancer cells, a nanozyme-based bimetallic metal-organic frameworks (MOFs) tandem reactor is fabricated to elevate intracellular H₂O₂ levels, thereby enhancing CDT. In addition, under near-infrared excitation, the upconversion nanoparticles (UCNPs) loaded into the MOFs can perform photocatalysis and generate hydrog

SUBMITTER: Zhong J 

PROVIDER: S-EPMC10761206 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature