Variation in antibiotic consumption in very preterm infants-a 10 year population-based study.

ABSTRACT:

Objectives

Wide variations in antibiotic use in very preterm infants have been reported across centres despite similar rates of infection. We describe 10 year trends in use of antibiotics and regional variations among very preterm infants in Norway.

Patients and methods

All live-born very preterm infants (<32 weeks gestation) admitted to any neonatal unit in Norway during 2009-18 were included. Main outcomes were antibiotic consumption expressed as days of antibiotic therapy (DOT) per 1000 patient days (PD), regional variations in use across four health regions, rates of sepsis and sepsis-attributable mortality and trends of antibiotic use during the study period.

Results

We included 5296 infants: 3646 (69%) were born at 28-31 weeks and 1650 (31%) were born before 28

SUBMITTER: Huncikova Z 

PROVIDER: S-EPMC10761275 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature