A higher number of exhausted local PD1+, but not TIM3+, NK cells in advanced endometriosis.

ABSTRACT: Endometriosis (EMT) is a chronic inflammatory disease characterized by the presence and growth of endometrial-like glandular epithelial and stromal cells outside the uterus. Natural Killer (NK) cell dysfunction/exhaustion has been shown in patients with EMT. In this case-control study, we compared the frequency of exhausted PD-1 or TIM-3 positive NK cells in peripheral blood (PB) and peritoneal fluid (PF) of women with advanced endometriosis to control fertile women. PB and PF were collected from women aged 25-40 who underwent the laparoscopic procedure, including 13 stages III/IV endometriosis and 13 control samples. Multicolor flowcytometry was used to compare the frequency of PD-1 or TIM-3 positive NK (CD3^-CD56⁺) cells in PB and PF of two groups. We demonstrated a h

SUBMITTER: Hosseinzadeh R 

PROVIDER: S-EPMC10761348 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature