Aberrant brain intra- and internetwork functional connectivity in children with Prader-Willi syndrome.

ABSTRACT:

Purpose

Prader-Willi syndrome (PWS) suffers from brain functional reorganization and developmental delays during childhood, but the underlying neurodevelopmental mechanism is unclear. This paper aims to investigate the intra- and internetwork functional connectivity (FC) changes, and their relationships with developmental delays in PWS children.

Methods

Resting-state functional magnetic resonance imaging datasets of PWS children and healthy controls (HCs) were acquired. Independent component analysis was used to acquire core resting-state networks (RSNs). The intra- and internetwork FC patterns were then investigated.

Results

In terms of intranetwork FC, children with PWS had lower FC in the dorsal attention network, the auditory network, the medial visual network (VN

SUBMITTER: Huang Z 

PROVIDER: S-EPMC10761436 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature