Micro simulated moving bed chromatography-mass spectrometry as a continuous on-line process analytical tool.

ABSTRACT: Continuous manufacturing is becoming increasingly important in the (bio-)pharmaceutical industry, as more product can be produced in less time and at lower costs. In this context, there is a need for powerful continuous analytical tools. Many established off-line analytical methods, such as mass spectrometry (MS), are hardly considered for process analytical technology (PAT) applications in biopharmaceutical processes, as they are limited to at-line analysis due to the required sample preparation and the associated complexity, although they would provide a suitable technique for the assessment of a wide range of quality attributes. In this study, we investigated the applicability of a recently developed micro simulated moving bed chromatography system (µSMB) for continuous on-line sample p

SUBMITTER: Diehm J 

PROVIDER: S-EPMC10761468 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature