Role of gut microbiota and inflammatory factors in acute respiratory distress syndrome: a Mendelian randomization analysis.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is a serious lung ailment marked by significant inflammation and damage in the alveoli and capillaries of the lungs. Recent research suggests a strong correlation between the onset and advancement of ARDS and an imbalance in the gut microbiota (GM).

Methods

In this investigation, Mendelian randomization (MR) analysis was utilized, drawing on data from publicly accessible genome-wide association studies. The primary focus was on examining the interplay between GM, inflammatory factors (IFs) and ARDS. Instrumental variables were established through genetic modifications of GM and IFs. Various statistical analysis methods including the inverse-variance weighted model, MR-Egger method and Wald ratio test were applied for comp

SUBMITTER: Ma J 

PROVIDER: S-EPMC10761488 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature