The peripheral immune cell counts and mouth ulcers: A two-sample Mendelian randomization study.

ABSTRACT:

Objective

This study explored the causal association of peripheral immune cell counts with mouth ulcers (MUs) by two-sample Mendelian Randomization.

Design

The counts of 12 circulating immune cell types (leukocytes, lymphocytes, monocytes, eosinophils, neutrophils, basophils, CD4⁺ cells, CD8⁺ cells, unswitched memory B cells, NK cells, B cells and a derived ratio (CD4+/CD8+)) were determined as the exposure. MUs were the outcome. The analysis was conducted mostly using the inverse-variance weighted (IVW) approach. MR Egger, weighted median, weighted mode and simple mode were used to detect the horizontal pleiotropy.

Results

The IVW results for leukocytes and lymphocyte counts were OR = 0.93, 95 % CI = 0.88-0.98, p = 0.0115 and OR = 0.91, 9

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10761572 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature