Biodistribution and radiation dosimetry of ¹²⁴I-mIBG in adult patients with neural crest tumours and extrapolation to paediatric models.

ABSTRACT:

Aim

Positron emission tomography (PET) using ¹²⁴I-mIBG has been established for imaging and pretherapeutic dosimetry. Here, we report the first systematic analysis of the biodistribution and radiation dosimetry of ¹²⁴I-mIBG in patients with neural crest tumours and project the results to paediatric patient models.

Methods

Adult patients with neural crest tumours who underwent sequential ¹²⁴I-mIBG PET were included in this retrospective single-center analysis. PET data were acquired 4, 24, 48, and/or 120 h after administration of a mean of 43 MBq ¹²⁴I-mIBG. Whole-body counting and blood sampling were performed at 2, 4, 24, 48 and 120 h after administration. Absorbed organ dose and effective dose coefficients were estimated in OLINDA

SUBMITTER: Moraitis A 

PROVIDER: S-EPMC10761661 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature