Fatty acid oxidation regulates cellular senescence by modulating the autophagy-SIRT1 axis.

ABSTRACT: Senescence, a cellular process through which damaged or dysfunctional cells suppress the cell cycle, contributes to aging or age-related functional decline. Cell metabolism has been closely correlated with aging processes, and it has been widely recognized that metabolic changes underlie the cellular alterations that occur with aging. Here, we report that fatty acid oxidation (FAO) serves as a critical regulator of cellular senescence and uncover the underlying mechanism by which FAO inhibition induces senescence. Pharmacological or genetic ablation of FAO results in a p53-dependent induction of cellular senescence in human fibroblasts, whereas enhancing FAO suppresses replicative senescence. We found that FAO inhibition promotes cellular senescence through acetyl-CoA, independent of energ

SUBMITTER: Yang S 

PROVIDER: S-EPMC10761749 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature