Histogram-based features track Alzheimer's progression in brain MRI.

ABSTRACT: Alzheimer's disease is a form of general dementia marked by amyloid plaques, neurofibrillary tangles, and neuron degeneration. The disease has no cure, and early detection is critical in improving patient outcomes. Magnetic resonance imaging (MRI) is important in measuring neurodegeneration during the disease. Computer-aided image processing tools have been used to aid medical professionals in ascertaining a diagnosis of Alzheimer's in its early stages. As characteristics of non and very-mild dementia stages overlap, tracking the progression is challenging. Our work developed an adaptive multi-thresholding algorithm based on the morphology of the smoothed histogram to define features identifying neurodegeneration and track its progression as non, very mild, mild, and moderate. Gray and whi

SUBMITTER: Pasnoori N 

PROVIDER: S-EPMC10761829 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature