Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity.

ABSTRACT: Purkinje cells in the cerebellum are among the largest neurons in the brain and have been extensively investigated in rodents. However, their morphological and physiological properties remain poorly understood in humans. In this study, we utilized high-resolution morphological reconstructions and unique electrophysiological recordings of human Purkinje cells ex vivo to generate computational models and estimate computational capacity. An inter-species comparison showed that human Purkinje cell had similar fractal structures but were larger than those of mouse Purkinje cells. Consequently, given a similar spine density (2/μm), human Purkinje cell hosted approximately 7.5 times more dendritic spines than those of mice. Moreover, human Purkinje cells had a higher dendritic complexity than mou

SUBMITTER: Masoli S 

PROVIDER: S-EPMC10761885 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature