Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets.

ABSTRACT: Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essential factor in maintaining cellular equilibrium, cellular zinc has been increasingly spotlighted in the context of disease development. Extensive research suggests zinc's involvement in promoting malignancy and invasion in cancer cells, despite its low tissue concentration. This has led to a growing body of literature investigating zinc's cellular metabolism, particularly the functions of zinc transporters and storage mechanisms during cancer progression. Zinc transportation is under the control of two major transporter families: SLC30 (ZnT) for the excretion of zinc and SLC39 (ZIP) fo

SUBMITTER: Chen B 

PROVIDER: S-EPMC10761908 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature