Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes.
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ABSTRACT:
SUBMITTER: Tsuno S
PROVIDER: S-EPMC10761928 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
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Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes.
Tsuno Saki S Harada Kazuki K Horikoshi Mina M Mita Marie M Kitaguchi Tetsuya T Hirai Masami Yokota MY Matsumoto Mitsuharu M Tsuboi Takashi T
FEBS open bio 20231213 1
Hepatocytes can switch their metabolic processes in response to nutrient availability. However, the dynamics of metabolites (such as lactate, pyruvate, and ATP) in hepatocytes during the metabolic switch remain unknown. In this study, we visualized metabolite dynamics in primary cultured hepatocytes during recovery from glucose-deprivation. We observed a decrease in the mitochondrial ATP concentration when glucose was administered to hepatocytes under glucose-deprivation conditions. In contrast, ...[more]
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