Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis.

ABSTRACT: Artificial organelles can manipulate cellular functions and introduce non-biological processes into cells. Coacervate droplets have emerged as a close analog of membraneless cellular organelles. Their biomimetic properties, such as molecular crowding and selective partitioning, make them promising components for designing cell-like materials. However, their use as artificial organelles has been limited by their complex molecular structure, limited control over internal microenvironment properties, and inherent colloidal instability. Here we report the design of dipeptide coacervates that exhibit enhanced stability, biocompatibility, and a hydrophobic microenvironment. The hydrophobic character facilitates the encapsulation of hydrophobic species, including transition metal-based catalysts,

SUBMITTER: Cao S 

PROVIDER: S-EPMC10761997 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature