Mapping causal links between prefrontal cortical regions and intra-individual behavioral variability.

ABSTRACT: Intra-individual behavioral variability is significantly heightened by aging or neuropsychological disorders, however it is unknown which brain regions are causally linked to such variabilities. We examine response time (RT) variability in 21 macaque monkeys performing a rule-guided decision-making task. In monkeys with selective-bilateral lesions in the anterior cingulate cortex (ACC) or in the dorsolateral prefrontal cortex, cognitive flexibility is impaired, but the RT variability is significantly diminished. Bilateral lesions within the frontopolar cortex or within the mid-dorsolateral prefrontal cortex, has no significant effect on cognitive flexibility or RT variability. In monkeys with lesions in the posterior cingulate cortex, the RT variability significantly increases without any

SUBMITTER: Alizadeh Mansouri F 

PROVIDER: S-EPMC10762061 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature