Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis.

ABSTRACT: Direct interactions between receptors at the neuronal surface have long been proposed to tune signaling cascades and neuronal communication in health and disease. Yet, the lack of direct investigation methods to measure, in live neurons, the interaction between different membrane receptors at the single molecule level has raised unanswered questions on the biophysical properties and biological roles of such receptor interactome. Using a multidimensional spectral single molecule-localization microscopy (MS-SMLM) approach, we monitored the interaction between two membrane receptors, i.e. glutamatergic NMDA (NMDAR) and G protein-coupled dopamine D1 (D1R) receptors. The transient interaction was randomly observed along the dendritic tree of hippocampal neurons. It was higher early in developme

SUBMITTER: Benac N 

PROVIDER: S-EPMC10762086 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature