MiR-373 promotes invasion and metastasis of colorectal cancer cells via activating ERK/MAPK pathway.

ABSTRACT: To explore the relationship between miR-373 and the occurrence and development of colorectal cancer. Additionally, it aims to predict the potential cellular signaling pathways and regulatory mechanisms in which miR-373 may be involved and provides a theoretical basis and experimental evidence for the clinical application of miR-373 as a potential biomarker, molecular target, and prognostic indicator in colorectal cancer. Real-time quantitative PCR is used to analyze the expression of miR-373 in human colorectal cancer cell lines and normal human colonic epithelial cells. Further validation of the differential expression of miR-373 in colorectal cancer cell lines is being performed. Biological functions such as cell proliferation, invasion and apoptosis are being detected by MTT, CCK-8, tra

SUBMITTER: Chen Q 

PROVIDER: S-EPMC10762131 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature