MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation.

ABSTRACT: Monocarboxylate transporter 1 (MCT1) exhibits essential roles in cellular metabolism and energy supply. Although MCT1 is highly expressed in activated B cells, it is not clear how MCT1-governed monocarboxylates transportation is functionally coupled to antibody production during the glucose metabolism. Here, we report that B cell-lineage deficiency of MCT1 significantly influences the class-switch recombination (CSR), rendering impaired IgG antibody responses in Mct1^f/fMb1^Cre mice after immunization. Metabolic flux reveals that glucose metabolism is significantly reprogrammed from glycolysis to oxidative phosphorylation in Mct1-deficient B cells upon activation. Consistently, activation-induced cytidine deaminase (AID), is severely suppressed in Mct1-deficient B cells

SUBMITTER: Chi W 

PROVIDER: S-EPMC10762154 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature